[HTML][HTML] Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis …
Z Jiang, HJ Johnson, H Nie, J Qin, TA Bird… - Journal of Biological …, 2003 - ASBMB
The signaling pathway downstream of the mammalian interleukin-1 receptor (IL-1R)/Toll-like
receptor (TLR) is evolutionally conserved with that mediated by theDrosophila Toll protein.
Toll initiates its signal through the adapter molecule Tube and the serine-threonine kinase
Pelle. Pelle is highly homologous to members of the IL-1R-associated kinase (IRAK) family
in mammals. Recently, a novel Pelle-interacting protein called Pellino was identified in
Drosophila. We now report a mammalian counterpart of Pellino, termed Pellino 1, which is …
receptor (TLR) is evolutionally conserved with that mediated by theDrosophila Toll protein.
Toll initiates its signal through the adapter molecule Tube and the serine-threonine kinase
Pelle. Pelle is highly homologous to members of the IL-1R-associated kinase (IRAK) family
in mammals. Recently, a novel Pelle-interacting protein called Pellino was identified in
Drosophila. We now report a mammalian counterpart of Pellino, termed Pellino 1, which is …