[HTML][HTML] Aβ oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug …
FG De Felice, PT Velasco, MP Lambert, K Viola… - Journal of Biological …, 2007 - ASBMB
Oxidative stress is a major aspect of Alzheimer disease (AD) pathology. We have
investigated the relationship between oxidative stress and neuronal binding of Aβ oligomers
(also known as ADDLs). ADDLs are known to accumulate in brain tissue of AD patients and
are considered centrally related to pathogenesis. Using hippocampal neuronal cultures, we
found that ADDLs stimulated excessive formation of reactive oxygen species (ROS) through
a mechanism requiring N-methyl-d-aspartate receptor (NMDA-R) activation. ADDL binding …
investigated the relationship between oxidative stress and neuronal binding of Aβ oligomers
(also known as ADDLs). ADDLs are known to accumulate in brain tissue of AD patients and
are considered centrally related to pathogenesis. Using hippocampal neuronal cultures, we
found that ADDLs stimulated excessive formation of reactive oxygen species (ROS) through
a mechanism requiring N-methyl-d-aspartate receptor (NMDA-R) activation. ADDL binding …