The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease
GM Cole, SA Frautschy - Experimental gerontology, 2007 - Elsevier
Although increased lifespan is associated with reduced insulin signaling, insulin signaling is
essential for neuronal development and survival. Insulin resistance is central to Type II
diabetes and is also implicated in the pathogenesis of Alzheimer's Disease (AD). This has
prompted ongoing clinical trials in AD patients to test the efficacy of improving insulin–like
signaling with dietary ω-3 fatty acids or insulin–sensitizing drugs as well as exercise
regimens. Here we review the role of insulin signaling in brain aging and AD, concluding …
essential for neuronal development and survival. Insulin resistance is central to Type II
diabetes and is also implicated in the pathogenesis of Alzheimer's Disease (AD). This has
prompted ongoing clinical trials in AD patients to test the efficacy of improving insulin–like
signaling with dietary ω-3 fatty acids or insulin–sensitizing drugs as well as exercise
regimens. Here we review the role of insulin signaling in brain aging and AD, concluding …