Pharmacokinetic interactions augment toxicities of sirolimus/cyclosporine combinations
H Podder, SM Stepkowski, KL Napoli… - Journal of the …, 2001 - journals.lww.com
This study correlated the dynamic effects of sirolimus (rapamycin; RAPA) and cyclosporine
(CsA) alone versus in combination to produce renal dysfunction, myelosuppression, or
hyperlipidemia, with their corresponding blood and tissue concentrations. After salt-depleted
rats were treated with RAPA (0.4 to 6.4 mg/kg per d) and/or CsA (2.5 to 20.0 mg/kg per d) for
14 d, the GFR, lipid levels, bone marrow cellularity, and CsA/RAPA concentrations in whole
blood versus liver or renal tissues were measured, and the median effect model was used to …
(CsA) alone versus in combination to produce renal dysfunction, myelosuppression, or
hyperlipidemia, with their corresponding blood and tissue concentrations. After salt-depleted
rats were treated with RAPA (0.4 to 6.4 mg/kg per d) and/or CsA (2.5 to 20.0 mg/kg per d) for
14 d, the GFR, lipid levels, bone marrow cellularity, and CsA/RAPA concentrations in whole
blood versus liver or renal tissues were measured, and the median effect model was used to …