Gene regulation by riboswitches
M Mandal, RR Breaker - Nature reviews Molecular cell biology, 2004 - nature.com
M Mandal, RR Breaker
Nature reviews Molecular cell biology, 2004•nature.comRiboswitches are complex folded RNA domains that serve as receptors for specific
metabolites. These domains are found in the non-coding portions of various mRNAs, where
they control gene expression by harnessing allosteric structural changes that are brought
about by metabolite binding. New findings indicate that riboswitches are robust genetic
elements that are involved in regulating fundamental metabolic processes in many
organisms.
metabolites. These domains are found in the non-coding portions of various mRNAs, where
they control gene expression by harnessing allosteric structural changes that are brought
about by metabolite binding. New findings indicate that riboswitches are robust genetic
elements that are involved in regulating fundamental metabolic processes in many
organisms.
Abstract
Riboswitches are complex folded RNA domains that serve as receptors for specific metabolites. These domains are found in the non-coding portions of various mRNAs, where they control gene expression by harnessing allosteric structural changes that are brought about by metabolite binding. New findings indicate that riboswitches are robust genetic elements that are involved in regulating fundamental metabolic processes in many organisms.
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