Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers
M Sabbah, S Emami, G Redeuilh, S Julien… - Drug resistance …, 2008 - Elsevier
The mechanisms involved in the epithelial to mesenchymal transition (EMT) are integrated
in concert with master developmental and oncogenic pathways regulating in tumor growth,
angiogenesis, metastasis, as well as the reprogrammation of specific gene repertoires
ascribed to both epithelial and mesenchymal cells. Consequently, it is not unexpected that
EMT has profound impacts on the neoplastic progression, patient survival, as well as the
resistance of cancers to therapeutics (taxol, vincristine, oxaliplatin, EGF-R targeted therapy …
in concert with master developmental and oncogenic pathways regulating in tumor growth,
angiogenesis, metastasis, as well as the reprogrammation of specific gene repertoires
ascribed to both epithelial and mesenchymal cells. Consequently, it is not unexpected that
EMT has profound impacts on the neoplastic progression, patient survival, as well as the
resistance of cancers to therapeutics (taxol, vincristine, oxaliplatin, EGF-R targeted therapy …