[HTML][HTML] Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity
A De La Mota-Peynado, J Chernoff, A Beeser - Journal of Biological …, 2011 - ASBMB
The class I p21-activated kinases (Pak1–3) regulate many essential biological processes,
including cytoskeletal rearrangement, cell cycle progression, apoptosis, and cellular
transformation. Although many Pak substrates, including elements of MAPK signaling
cascades, have been identified, it is likely that additional substrates remain to be discovered.
Identification of such substrates, and determination of the consequences of their
phosphorylation, is essential for a better understanding of class I Pak activity. To identify …
including cytoskeletal rearrangement, cell cycle progression, apoptosis, and cellular
transformation. Although many Pak substrates, including elements of MAPK signaling
cascades, have been identified, it is likely that additional substrates remain to be discovered.
Identification of such substrates, and determination of the consequences of their
phosphorylation, is essential for a better understanding of class I Pak activity. To identify …