Tumour necrosis factor α: a potential target for the therapy of solid tumours
PW Szlosarek, FR Balkwill - The lancet oncology, 2003 - thelancet.com
PW Szlosarek, FR Balkwill
The lancet oncology, 2003•thelancet.comReview Tumour necrosis factor α has been emphasised. 9, 10 As a central mediator of
inflammation, TNFα provides a molecular link between chronic inflammatory stimuli and the
subsequent development of malignant disease. Its paradoxical role in cancer progression
has stimulated interest in the use of TNFα antagonists for the prevention and treatment of
cancer. The use of TNFα antagonists in haematological cancers has recently been
discussed, providing a rationale for their clinical use. 11 In this review, we concentrate on …
inflammation, TNFα provides a molecular link between chronic inflammatory stimuli and the
subsequent development of malignant disease. Its paradoxical role in cancer progression
has stimulated interest in the use of TNFα antagonists for the prevention and treatment of
cancer. The use of TNFα antagonists in haematological cancers has recently been
discussed, providing a rationale for their clinical use. 11 In this review, we concentrate on …
Review Tumour necrosis factor α has been emphasised. 9, 10 As a central mediator of inflammation, TNFα provides a molecular link between chronic inflammatory stimuli and the subsequent development of malignant disease. Its paradoxical role in cancer progression has stimulated interest in the use of TNFα antagonists for the prevention and treatment of cancer. The use of TNFα antagonists in haematological cancers has recently been discussed, providing a rationale for their clinical use. 11 In this review, we concentrate on the case for modulating TNFα in solid tumours.
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