Medullary serotonin neurons and central CO2 chemoreception
AE Corcoran, MR Hodges, Y Wu, W Wang… - Respiratory physiology …, 2009 - Elsevier
Serotonergic (5-HT) neurons are putative central respiratory chemoreceptors, aiding in the
brain's ability to detect arterial changes in [Formula: see text] and implement appropriate
ventilatory responses to maintain blood homeostasis. These neurons are in close proximity
to large medullary arteries and are intrinsically chemosensitive in vitro, characteristics
expected for chemoreceptors. 5-HT neurons of the medullary raphé are stimulated by
hypercapnia in vivo, and their disruption results in a blunted hypercapnic ventilatory …
brain's ability to detect arterial changes in [Formula: see text] and implement appropriate
ventilatory responses to maintain blood homeostasis. These neurons are in close proximity
to large medullary arteries and are intrinsically chemosensitive in vitro, characteristics
expected for chemoreceptors. 5-HT neurons of the medullary raphé are stimulated by
hypercapnia in vivo, and their disruption results in a blunted hypercapnic ventilatory …