[HTML][HTML] Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia
I Pitha-Rowe, BA Hassel, E Dmitrovsky - Journal of Biological Chemistry, 2004 - ASBMB
Acute promyelocytic leukemia (APL) cases expressing the t (15, 17) product, promyelocytic
leukemia (PML)/retinoic acid receptor α (RARα), have clinical remissions through leukemic
cell differentiation after all-trans-retinoic acid (RA) treatment. This differentiation therapy
propelled interest in uncovering molecular mechanisms for RA-dependent APL
differentiation. We previously identified the ubiquitin-activating enzyme-E1-like protein
(UBE1L) as an RA-regulated target gene in APL that triggers PML/RARα degradation and …
leukemia (PML)/retinoic acid receptor α (RARα), have clinical remissions through leukemic
cell differentiation after all-trans-retinoic acid (RA) treatment. This differentiation therapy
propelled interest in uncovering molecular mechanisms for RA-dependent APL
differentiation. We previously identified the ubiquitin-activating enzyme-E1-like protein
(UBE1L) as an RA-regulated target gene in APL that triggers PML/RARα degradation and …