NMDA receptor function, neuroplasticity, and the pathophysiology of schizophrenia

JT Coyle, G Tsai - International review of neurobiology, 2004 - Elsevier
Schizophrenia is a disorder that affects approximately 1% of adults with little variation in
prevalence throughout the world. It affects multiple domains, resulting in hallucinations and
delusions (positive symptoms), lack of initiative, emotional impoverishment, and poor social
skills (negative symptoms), and impairments in memory and problem solving (cognitive
symptoms). Although positive symptoms wax and wane, negative symptoms and cognitive
impairments are more enduring, cause greater disability, and correlate with cortical …