Treatment of ALS with high dose pulse cyclophosphamide
SA Smith, RG Miller, JR Murphy, SP Ringel - Journal of the neurological …, 1994 - Elsevier
Autoimmune abnormalities have been described in sporadically acquired amyotrophic
lateral sclerosis (ALS), but ALS patients do not benefit from conventional
immunosuppressive therapy. Because Multifocal Motor Neuropathy causes a syndrome
mimicking the lower motor neuron involvement in ALS and responds to high dose
cyclophosphamide, we tested whether ALS patients would respond to the same treatment.
Eighteen patients with classical ALS initially received a high loading dose of intravenous …
lateral sclerosis (ALS), but ALS patients do not benefit from conventional
immunosuppressive therapy. Because Multifocal Motor Neuropathy causes a syndrome
mimicking the lower motor neuron involvement in ALS and responds to high dose
cyclophosphamide, we tested whether ALS patients would respond to the same treatment.
Eighteen patients with classical ALS initially received a high loading dose of intravenous …