MicroRNAs (miRNAs) are short, non-coding RNAs that target and silence protein coding
genes through 3′-UTR elements. Evidence increasingly assigns an immunosuppressive
role for miRNAs in immunity, but relatively few miRNAs have been studied, and an overall
understanding of the importance of these regulatory transcripts in complex in vivo systems is
lacking. Here we have applied multiple technologies to globally analyze miRNA expression
and function in allergic lung disease, an experimental model of asthma. Deep sequencing …