Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process
S Mantovani, S Garbelli, A Pasini, D Alimonti… - Journal of …, 2009 - Elsevier
In this work we show that patients with sporadic amyotrophic lateral sclerosis exhibit
immunological alterations in their blood, with respect to healthy controls, such as: i)
increased levels of CD4+ cells and decreased levels of CD8+ T lymphocytes, the latter due
to the reduced expression of the anti-apoptotic molecule Bcl-2; ii) significantly reduced
CD4+ CD25+ regulatory T (Treg) cells and monocytes (CD14+) levels in patients at a less
severe stage of disease, suggesting their early recruitment towards the CNS area of primary …
immunological alterations in their blood, with respect to healthy controls, such as: i)
increased levels of CD4+ cells and decreased levels of CD8+ T lymphocytes, the latter due
to the reduced expression of the anti-apoptotic molecule Bcl-2; ii) significantly reduced
CD4+ CD25+ regulatory T (Treg) cells and monocytes (CD14+) levels in patients at a less
severe stage of disease, suggesting their early recruitment towards the CNS area of primary …