[HTML][HTML] Ligand-independent and-dependent Functions of Thyroid Hormone Receptor Isoforms Depend upon Their Distinct Amino Termini∗
AN Hollenberg, T Monden, FE Wondisford - Journal of Biological Chemistry, 1995 - ASBMB
Isoform specificity likely plays a large role in the ability of the thyroid hormone receptor (TR)
to specifically regulate gene expression in both the presence and absence of its cognate
ligand, triiodothyronine. To investigate further the mechanism of isoform specificity of human
TRs (TRα1 and TRβ1), we have examined their functional effects on positive thyroid
hormone response elements (TREs) both in the presence and absence of ligand. TRα1 was
greater than 2-fold more potent than TRβ1 on both TREs studied, in terms of both ligand …
to specifically regulate gene expression in both the presence and absence of its cognate
ligand, triiodothyronine. To investigate further the mechanism of isoform specificity of human
TRs (TRα1 and TRβ1), we have examined their functional effects on positive thyroid
hormone response elements (TREs) both in the presence and absence of ligand. TRα1 was
greater than 2-fold more potent than TRβ1 on both TREs studied, in terms of both ligand …
