[PDF][PDF] Functional FGFR4 Gly388Arg polymorphism predicts prognosis in lung adenocarcinoma patients
M Spinola, V Leoni, C Pignatiello, B Conti… - J Clin …, 2005 - researchgate.net
M Spinola, V Leoni, C Pignatiello, B Conti, F Ravagnani, U Pastorino, TA Dragani
J Clin Oncol, 2005•researchgate.netPurpose Fibroblast growth factor receptor 4 (FGFR4) is a member of a family of
transmembrane receptors with ligand-induced tyrosine kinase activity. The Gly388Arg
polymorphism in the FGFR4 gene was reported to modulate cancer cell migration in vitro
and to be associated with breast, colon, and prostate cancer prognostic parameters. The
purpose of this study was to investigate the involvement of the FGFR4 polymorphism in lung
tumorigenesis.
transmembrane receptors with ligand-induced tyrosine kinase activity. The Gly388Arg
polymorphism in the FGFR4 gene was reported to modulate cancer cell migration in vitro
and to be associated with breast, colon, and prostate cancer prognostic parameters. The
purpose of this study was to investigate the involvement of the FGFR4 polymorphism in lung
tumorigenesis.
Purpose
Fibroblast growth factor receptor 4 (FGFR4) is a member of a family of transmembrane receptors with ligand-induced tyrosine kinase activity. The Gly388Arg polymorphism in the FGFR4 gene was reported to modulate cancer cell migration in vitro and to be associated with breast, colon, and prostate cancer prognostic parameters. The purpose of this study was to investigate the involvement of the FGFR4 polymorphism in lung tumorigenesis.
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