[HTML][HTML] Lung Cell-specific Expression of the Murine Surfactant Protein A (SP-A) Gene Is Mediated by Interactions between the SP-A Promoter and Thyroid …
MD Bruno, RJ Bohinski, KM Huelsman… - Journal of Biological …, 1995 - ASBMB
Cis-acting elements determining lung epithelial cell-selective transcription of the murine
surfactant protein A (SP-A) gene were identified between nucleotide positions− 255 and−
57. This region of the murine SP-A gene contained nucleotide sequences consistent with
thyroid transcription factor-1 (TTF-1) binding motifs. An SP-A-CAT plasmid containing the
TTF-1 binding sites was transcriptionally active in mouse lung epithelial (MLE-15) cells but
not in HeLa, 3T3, or H441 cells. However, transcription of the SP-A-CAT construct was …
surfactant protein A (SP-A) gene were identified between nucleotide positions− 255 and−
57. This region of the murine SP-A gene contained nucleotide sequences consistent with
thyroid transcription factor-1 (TTF-1) binding motifs. An SP-A-CAT plasmid containing the
TTF-1 binding sites was transcriptionally active in mouse lung epithelial (MLE-15) cells but
not in HeLa, 3T3, or H441 cells. However, transcription of the SP-A-CAT construct was …