[HTML][HTML] Tissue-specific alternative splicing generates two synaptojanin isoforms with differential membrane binding properties
AR Ramjaun, PS McPherson - Journal of Biological Chemistry, 1996 - ASBMB
Synaptojanin is an Src homology 3 domain-binding inositol 5-phosphatase that is thought to
function in synaptic vesicle endocytosis. It is encoded by a cDNA with two open reading
frames separated by an in-frame stop codon. The first open reading frame encodes a 145-
kDa form of the protein, whereas a 170-kDa isoform appears to be composed of both open
reading frames and contains additional Src homology 3 domain-binding consensus
sequences. Here, we demonstrate that the two synaptojanin isoforms are generated by the …
function in synaptic vesicle endocytosis. It is encoded by a cDNA with two open reading
frames separated by an in-frame stop codon. The first open reading frame encodes a 145-
kDa form of the protein, whereas a 170-kDa isoform appears to be composed of both open
reading frames and contains additional Src homology 3 domain-binding consensus
sequences. Here, we demonstrate that the two synaptojanin isoforms are generated by the …