[PDF][PDF] A new Gq-initiated MAPK signaling pathway in the heart
JS Gutkind, S Offermanns - Developmental cell, 2009 - cell.com
Developmental cell, 2009•cell.com
Pathological cardiac hypertrophy involves auto/paracrine mediators acting through G q/11-
coupled receptors. A novel signaling route stimulated by βγ-subunits of G q/11 results in the
autophosphorylation of ERK1/2 on a new site and the nuclear retention of ERK1/2, thereby
activating hypertrophic gene programs.
coupled receptors. A novel signaling route stimulated by βγ-subunits of G q/11 results in the
autophosphorylation of ERK1/2 on a new site and the nuclear retention of ERK1/2, thereby
activating hypertrophic gene programs.
Pathological cardiac hypertrophy involves auto/paracrine mediators acting through Gq/11-coupled receptors. A novel signaling route stimulated by βγ-subunits of Gq/11 results in the autophosphorylation of ERK1/2 on a new site and the nuclear retention of ERK1/2, thereby activating hypertrophic gene programs.
cell.com