[HTML][HTML] Unchain my heart: the scientific foundations of cardiac repair

S Dimmeler, AM Zeiher… - The Journal of clinical …, 2005 - Am Soc Clin Investig
S Dimmeler, AM Zeiher, MD Schneider
The Journal of clinical investigation, 2005Am Soc Clin Investig
In humans, the biological limitations to cardiac regenerative growth create both a clinical
imperative—to offset cell death in acute ischemic injury and chronic heart failure—and a
clinical opportunity; that is, for using cells, genes, and proteins to rescue cardiac muscle cell
number or in other ways promote more efficacious cardiac repair. Recent experimental
studies and early-phase clinical trials lend credence to the visionary goal of enhancing
cardiac repair as an achievable therapeutic target.
In humans, the biological limitations to cardiac regenerative growth create both a clinical imperative — to offset cell death in acute ischemic injury and chronic heart failure — and a clinical opportunity; that is, for using cells, genes, and proteins to rescue cardiac muscle cell number or in other ways promote more efficacious cardiac repair. Recent experimental studies and early-phase clinical trials lend credence to the visionary goal of enhancing cardiac repair as an achievable therapeutic target.
The Journal of Clinical Investigation