[PDF][PDF] Rewind to recover: dedifferentiation after cardiac injury
EE Morrisey - Cell Stem Cell, 2011 - cell.com
EE Morrisey
Cell Stem Cell, 2011•cell.comIn adult mammals, cardiomyocytes are known to reactivate an embryonic gene-expression
program after injury. In this issue of Cell Stem Cell, Kubin et al.(2011) show that oncostatin M
regulates this dedifferentiation which, while beneficial for recovery from acute injury, if
persistent results in heart failure in both rodents and humans.
program after injury. In this issue of Cell Stem Cell, Kubin et al.(2011) show that oncostatin M
regulates this dedifferentiation which, while beneficial for recovery from acute injury, if
persistent results in heart failure in both rodents and humans.
In adult mammals, cardiomyocytes are known to reactivate an embryonic gene-expression program after injury. In this issue of Cell Stem Cell, Kubin et al. (2011) show that oncostatin M regulates this dedifferentiation which, while beneficial for recovery from acute injury, if persistent results in heart failure in both rodents and humans.
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