The inhibitory FcγRIIb modulates the inflammatory response and influences atherosclerosis in male apoE−/− mice
YV Mendez-Fernandez, BG Stevenson, CJ Diehl… - Atherosclerosis, 2011 - Elsevier
BACKGROUND: Atherosclerosis is widely accepted as an inflammatory disease involving
both innate and adaptive immunity. B cells and/or antibodies have previously been shown to
play a protective role against atherosclerosis. Aside from their ability to bind to antigens,
antibodies can influence inflammatory responses by interacting with various Fcγ receptors
on the surface of antigen presenting cells. Although studies in mice have determined that
stimulatory Fcγ receptors contribute to atherosclerosis, the role of the inhibitory Fcγ receptor …
both innate and adaptive immunity. B cells and/or antibodies have previously been shown to
play a protective role against atherosclerosis. Aside from their ability to bind to antigens,
antibodies can influence inflammatory responses by interacting with various Fcγ receptors
on the surface of antigen presenting cells. Although studies in mice have determined that
stimulatory Fcγ receptors contribute to atherosclerosis, the role of the inhibitory Fcγ receptor …