Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome
S Clark, J Schwalbe, MR Stasko, PJ Yarowsky… - Experimental …, 2006 - Elsevier
S Clark, J Schwalbe, MR Stasko, PJ Yarowsky, ACS Costa
Experimental neurology, 2006•ElsevierThe Ts65Dn mouse, an adult model of Down syndrome displays behavioral deficits
consistent with a dysfunctional hippocampus, similar to that seen with DS. In looking for
mechanisms underlying these performance deficits, we have assessed adult neurogenesis
in the dentate gyrus of Ts65Dn. Under untreated conditions, Ts65Dn mice (2–5 months old)
showed markedly fewer BrdU-labeled cells than euploid animals. Chronic antidepressant
treatment for over 3 weeks with the serotonin selective reuptake inhibitor, fluoxetine …
consistent with a dysfunctional hippocampus, similar to that seen with DS. In looking for
mechanisms underlying these performance deficits, we have assessed adult neurogenesis
in the dentate gyrus of Ts65Dn. Under untreated conditions, Ts65Dn mice (2–5 months old)
showed markedly fewer BrdU-labeled cells than euploid animals. Chronic antidepressant
treatment for over 3 weeks with the serotonin selective reuptake inhibitor, fluoxetine …
The Ts65Dn mouse, an adult model of Down syndrome displays behavioral deficits consistent with a dysfunctional hippocampus, similar to that seen with DS. In looking for mechanisms underlying these performance deficits, we have assessed adult neurogenesis in the dentate gyrus of Ts65Dn. Under untreated conditions, Ts65Dn mice (2–5 months old) showed markedly fewer BrdU-labeled cells than euploid animals. Chronic antidepressant treatment for over 3 weeks with the serotonin selective reuptake inhibitor, fluoxetine, increased neurogenesis in the Ts65Dn to comparable levels seen in the euploid by augmenting both proliferation and survival of BrdU-labeled cells in the subgranular layer and granule cell layer of the hippocampus, respectively.
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