Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility
C Li, S Zheng, H You, X Liu, M Lin, L Yang, L Li - Journal of hepatology, 2011 - Elsevier
BACKGROUND & AIMS: Directed migration of hepatic myofibroblasts (hMFs) contributes to
the development of liver fibrosis. However, the signals regulating the motility of these cells
are incompletely understood. We have recently shown that sphingosine 1-phosphate (S1P)
and S1P receptors (S1PRs) are involved in mouse liver fibrogenesis. Here, we investigated
the role of S1P/S1PRs signals in human liver fibrosis involving motility of human hMFs.
METHODS: S1P level in the liver was examined by high-performance liquid …
the development of liver fibrosis. However, the signals regulating the motility of these cells
are incompletely understood. We have recently shown that sphingosine 1-phosphate (S1P)
and S1P receptors (S1PRs) are involved in mouse liver fibrogenesis. Here, we investigated
the role of S1P/S1PRs signals in human liver fibrosis involving motility of human hMFs.
METHODS: S1P level in the liver was examined by high-performance liquid …