Sirolimus therapy predisposes to new-onset diabetes mellitus after renal transplantation: a long-term analysis of various treatment regimens
E Gyurus, Z Kaposztas, BD Kahan - Transplantation proceedings, 2011 - Elsevier
Purpose This retrospective analysis evaluated the impacts of sirolimus (SRL), cyclosporine
(CsA), and steroids (S) on the occurrence, treatment, and complications of new-onset
diabetes after transplantation (NODAT). Methods We compared 4 groups: group 1, SRL plus
full-exposure CsA/S (n= 118); group 2, full-exposure CsA/S/no SRL±antiproliferative drug
(n= 141); group 3, SRL plus reduced CsA exposure/S (n= 212); and group 4, no SRL/full-
exposure CsA/S±antiproliferative drug (n= 43). Results NODAT rates reflected the level of …
(CsA), and steroids (S) on the occurrence, treatment, and complications of new-onset
diabetes after transplantation (NODAT). Methods We compared 4 groups: group 1, SRL plus
full-exposure CsA/S (n= 118); group 2, full-exposure CsA/S/no SRL±antiproliferative drug
(n= 141); group 3, SRL plus reduced CsA exposure/S (n= 212); and group 4, no SRL/full-
exposure CsA/S±antiproliferative drug (n= 43). Results NODAT rates reflected the level of …