[HTML][HTML] Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts
JH Chen, K Stoeber, S Kingsbury, SE Ozanne… - Journal of Biological …, 2004 - ASBMB
Cellular senescence can result from short, dysfunctional telomeres, oxidative stress, or
oncogene expression, and may contribute to aging. To investigate the role of cellular
senescence in aging it is necessary to define the time-dependent molecular events by which
it is characterized. Here we investigated changes in levels of key proteins involved in cell
cycle regulation, DNA replication, and stress resistance in senescing human fibroblasts
following oxidative stress. An immediate response in stressed cells was dephosphorylation …
oncogene expression, and may contribute to aging. To investigate the role of cellular
senescence in aging it is necessary to define the time-dependent molecular events by which
it is characterized. Here we investigated changes in levels of key proteins involved in cell
cycle regulation, DNA replication, and stress resistance in senescing human fibroblasts
following oxidative stress. An immediate response in stressed cells was dephosphorylation …