[HTML][HTML] Wnt/β-catenin signaling in development and disease

H Clevers - Cell, 2006 - cell.com
Cell, 2006cell.com
A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal
transduction cascade over the last two decades. Wnt genes encode small secreted proteins
that are found in all animal genomes. Wnt signaling is involved in virtually every aspect of
embryonic development and also controls homeostatic self-renewal in a number of adult
tissues. Germline mutations in the Wnt pathway cause several hereditary diseases, and
somatic mutations are associated with cancer of the intestine and a variety of other tissues.
A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades. Wnt genes encode small secreted proteins that are found in all animal genomes. Wnt signaling is involved in virtually every aspect of embryonic development and also controls homeostatic self-renewal in a number of adult tissues. Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.
cell.com