Immunology beats cancer: a blueprint for successful translation
DM Pardoll - Nature immunology, 2012 - nature.com
Nature immunology, 2012•nature.com
Immunology offers an unprecedented opportunity for the science-driven development of
therapeutics. The successes of antibodies to the immunomodulatory receptor CTLA-4 and
blockade of the immunoinhibitory receptor PD-1 in cancer immunotherapy, from gene
discovery to patient benefit, have created a paradigm for driving such endeavors.
therapeutics. The successes of antibodies to the immunomodulatory receptor CTLA-4 and
blockade of the immunoinhibitory receptor PD-1 in cancer immunotherapy, from gene
discovery to patient benefit, have created a paradigm for driving such endeavors.
Abstract
Immunology offers an unprecedented opportunity for the science-driven development of therapeutics. The successes of antibodies to the immunomodulatory receptor CTLA-4 and blockade of the immunoinhibitory receptor PD-1 in cancer immunotherapy, from gene discovery to patient benefit, have created a paradigm for driving such endeavors.
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