Maturity onset diabetes of the young (MODY) is an autosomal dominant disease. Despite
extensive research, the mechanism by which a mutant MODY gene results in monogenic
diabetes is not yet clear due to the inaccessibility of patient samples. Induced pluripotency
and directed differentiation toward the pancreatic lineage are now viable and attractive
methods to uncover the molecular mechanisms underlying MODY. Here we report, for the
first time, the derivation of human induced pluripotent stem cells (hiPSCs) from patients with …