[HTML][HTML] The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions?
AG Pockley, SK Calderwood, G Multhoff - Cell stress and Chaperones, 2009 - Elsevier
Although heat shock (stress) proteins are typically regarded as being exclusively
intracellular molecules, it is now apparent that they can be released from cells in the
absence of cellular necrosis. We and others have reported the presence of Hsp60 (HSPD1)
and Hsp70 (HSPA1A) in the circulation of normal individuals and our finding that increases
in carotid intima-media thicknesses (a measure of atherosclerosis) in subjects with
hypertension at a 4-year follow-up are less prevalent in those having high serum Hsp70 …
intracellular molecules, it is now apparent that they can be released from cells in the
absence of cellular necrosis. We and others have reported the presence of Hsp60 (HSPD1)
and Hsp70 (HSPA1A) in the circulation of normal individuals and our finding that increases
in carotid intima-media thicknesses (a measure of atherosclerosis) in subjects with
hypertension at a 4-year follow-up are less prevalent in those having high serum Hsp70 …