[HTML][HTML] Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells
JR Thériault, SS Mambula, T Sawamura… - FEBS letters, 2005 - Elsevier
JR Thériault, SS Mambula, T Sawamura, MA Stevenson, SK Calderwood
FEBS letters, 2005•ElsevierExtracellular HSP70 has been found to participate in both innate and adaptive immune
responses. However, little is known about the molecular mechanisms that mediate this
process. Previous reports suggest that HSP70 interacts with antigen presenting cells (APC)
through a plethora of surface receptors. In this study, we have examined the relative binding
of potential HSP70 receptors and found high affinity binding to LOX-1 but not other
structures with a role in HSP70–APC interactions such as LRP/CD91, CD40, TLR2, TLR4 or …
responses. However, little is known about the molecular mechanisms that mediate this
process. Previous reports suggest that HSP70 interacts with antigen presenting cells (APC)
through a plethora of surface receptors. In this study, we have examined the relative binding
of potential HSP70 receptors and found high affinity binding to LOX-1 but not other
structures with a role in HSP70–APC interactions such as LRP/CD91, CD40, TLR2, TLR4 or …
Extracellular HSP70 has been found to participate in both innate and adaptive immune responses. However, little is known about the molecular mechanisms that mediate this process. Previous reports suggest that HSP70 interacts with antigen presenting cells (APC) through a plethora of surface receptors. In this study, we have examined the relative binding of potential HSP70 receptors and found high affinity binding to LOX-1 but not other structures with a role in HSP70–APC interactions such as LRP/CD91, CD40, TLR2, TLR4 or another c-type lectin family member (DC-SIGN) closely related to LOX-1. In addition to APC, HSP70 can avidly bind to non-APC cell lines, especially those from epithelial or endothelial background.
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