Tubular expression of KIM-1 does not predict delayed function after transplantation
B Schröppel, B Krüger, L Walsh, M Yeung… - Journal of the …, 2010 - journals.lww.com
Injured epithelial cells of the proximal tubule upregulate the glycoprotein kidney injury
molecule 1 (KIM-1), suggesting its potential as a biomarker of incipient kidney allograft
injury. It is unknown whether KIM-1 expression changes in kidney allografts with delayed
graft function (DGF), which often follows ischemia-reperfusion injury. Here, we prospectively
measured KIM-1 RNA and protein expression in preperfusion biopsies of 30 living-and 85
deceased-donor kidneys and correlated the results with histologic and clinical outcomes …
molecule 1 (KIM-1), suggesting its potential as a biomarker of incipient kidney allograft
injury. It is unknown whether KIM-1 expression changes in kidney allografts with delayed
graft function (DGF), which often follows ischemia-reperfusion injury. Here, we prospectively
measured KIM-1 RNA and protein expression in preperfusion biopsies of 30 living-and 85
deceased-donor kidneys and correlated the results with histologic and clinical outcomes …
