[HTML][HTML] ICER-1γ overexpression drives palmitate-mediated connexin36 down-regulation in insulin-secreting cells
Channels formed by the gap junction protein connexin36 (Cx36) contribute to the proper
control of insulin secretion. We investigated the impact of chronic hyperlipidemia on Cx36
expression in pancreatic β-cells. Prolonged exposure to the saturated free fatty acid
palmitate reduced the expression of Cx36 in several insulin-secreting cell lines and isolated
mouse islets. The effect of palmitate was fully blocked upon protein kinase A (PKA) inhibition
by H89 and (Rp)-cAMP, indicating that the cAMP/PKA pathway is involved in the control of …
control of insulin secretion. We investigated the impact of chronic hyperlipidemia on Cx36
expression in pancreatic β-cells. Prolonged exposure to the saturated free fatty acid
palmitate reduced the expression of Cx36 in several insulin-secreting cell lines and isolated
mouse islets. The effect of palmitate was fully blocked upon protein kinase A (PKA) inhibition
by H89 and (Rp)-cAMP, indicating that the cAMP/PKA pathway is involved in the control of …