Tailoring cAMP-signalling responses through isoform multiplicity
MD Houslay, G Milligan - Trends in biochemical sciences, 1997 - cell.com
MD Houslay, G Milligan
Trends in biochemical sciences, 1997•cell.comMultiple forms of cAMP phosphodiesterases (PDE), adenylate cyclase and protein kinase A
(PKA) allow cells to tailor the responsiveness of the cAMP-signalling system and to allow for
its dynamic adjustment. Multiple forms of these enzymes confer spatial and temporal
characteristics on cAMP signalling so as to affect compartmentalised responses within a
single cell type. The ability to breach the PKA activation threshold can depend upon either or
both the activation of adenylate cyclase and inhibition of specific PDE isoforms.
(PKA) allow cells to tailor the responsiveness of the cAMP-signalling system and to allow for
its dynamic adjustment. Multiple forms of these enzymes confer spatial and temporal
characteristics on cAMP signalling so as to affect compartmentalised responses within a
single cell type. The ability to breach the PKA activation threshold can depend upon either or
both the activation of adenylate cyclase and inhibition of specific PDE isoforms.
Abstract
Multiple forms of cAMP phosphodiesterases (PDE), adenylate cyclase and protein kinase A (PKA) allow cells to tailor the responsiveness of the cAMP-signalling system and to allow for its dynamic adjustment. Multiple forms of these enzymes confer spatial and temporal characteristics on cAMP signalling so as to affect compartmentalised responses within a single cell type. The ability to breach the PKA activation threshold can depend upon either or both the activation of adenylate cyclase and inhibition of specific PDE isoforms.
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