Transcriptional regulation of effector and memory CD8+ T cell fates
JED Thaventhiran, DT Fearon, L Gattinoni - Current opinion in immunology, 2013 - Elsevier
JED Thaventhiran, DT Fearon, L Gattinoni
Current opinion in immunology, 2013•ElsevierImmunity to intracellular pathogens and cancer relies on the generation of robust CD8+ T
cell effector responses as well as the establishment of immunological memory. During a
primary immune response CD8+ T cells experience diverse extracellular environmental
cues and cell–cell interactions that trigger downstream transcriptional programs ultimately
guiding a CD8+ T cell to undertake either an effector or a memory cell fate. Here, we discuss
our current understanding of the signaling pathways and transcriptional networks that …
cell effector responses as well as the establishment of immunological memory. During a
primary immune response CD8+ T cells experience diverse extracellular environmental
cues and cell–cell interactions that trigger downstream transcriptional programs ultimately
guiding a CD8+ T cell to undertake either an effector or a memory cell fate. Here, we discuss
our current understanding of the signaling pathways and transcriptional networks that …
Immunity to intracellular pathogens and cancer relies on the generation of robust CD8+ T cell effector responses as well as the establishment of immunological memory. During a primary immune response CD8+ T cells experience diverse extracellular environmental cues and cell–cell interactions that trigger downstream transcriptional programs ultimately guiding a CD8+ T cell to undertake either an effector or a memory cell fate. Here, we discuss our current understanding of the signaling pathways and transcriptional networks that regulate effector and memory commitment in CD8+ T lymphocytes.
Elsevier
