HDAC6 α-tubulin deacetylase: a potential therapeutic target in neurodegenerative diseases
G Li, H Jiang, M Chang, H Xie, L Hu - Journal of the neurological sciences, 2011 - Elsevier
Histone deacetylases (HDACs), or lysine deacetylases (KDAC), are epigenetic regulators
that catalyze the removal of acetyl moieties from the tails of lysine residues of histones and
other proteins. To date, eighteen HDAC family members (HDAC1-11 and SIRT1-7) have
been identified and grouped into four classes according to their homology to yeast histone
deacetylases. HDACs play an important role in regulating gene transcription as well as a
variety of cellular functions. Recent studies have found that HDAC6 (α-tubulin deacetylase) …
that catalyze the removal of acetyl moieties from the tails of lysine residues of histones and
other proteins. To date, eighteen HDAC family members (HDAC1-11 and SIRT1-7) have
been identified and grouped into four classes according to their homology to yeast histone
deacetylases. HDACs play an important role in regulating gene transcription as well as a
variety of cellular functions. Recent studies have found that HDAC6 (α-tubulin deacetylase) …