[HTML][HTML] The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone
VA Rao, SR Klein, SJ Bonar, J Zielonka… - Journal of Biological …, 2010 - ASBMB
Mitoquinone (MitoQ) is a synthetically modified, redox-active ubiquinone compound that
accumulates predominantly in mitochondria. We found that MitoQ is 30-fold more cytotoxic to
breast cancer cells than to healthy mammary cells. MitoQ treatment led to irreversible
inhibition of clonogenic growth of breast cancer cells through a combination of autophagy
and apoptotic cell death mechanisms. Relatively limited cytotoxicity was seen with the
parent ubiquinone coenzyme Q 10. Inhibition of cancer cell growth by MitoQ was associated …
accumulates predominantly in mitochondria. We found that MitoQ is 30-fold more cytotoxic to
breast cancer cells than to healthy mammary cells. MitoQ treatment led to irreversible
inhibition of clonogenic growth of breast cancer cells through a combination of autophagy
and apoptotic cell death mechanisms. Relatively limited cytotoxicity was seen with the
parent ubiquinone coenzyme Q 10. Inhibition of cancer cell growth by MitoQ was associated …