Stats: transcriptional control and biological impact

DE Levy, JE Darnell Jr - Nature reviews Molecular cell biology, 2002 - nature.com
DE Levy, JE Darnell Jr
Nature reviews Molecular cell biology, 2002nature.com
Extracellular proteins bound to cell-surface receptors can change nuclear gene expression
patterns in minutes, with far-reaching consequences for development, cell growth and
homeostasis. The signal transducer and activator of transcription (STAT) proteins are among
the most well studied of the latent cytoplasmic signal-dependent transcription-factor
pathways. In addition to several roles in normal cell decisions, dysregulation of STAT
function contributes to human disease, making the study of these proteins an important topic …
Abstract
Extracellular proteins bound to cell-surface receptors can change nuclear gene expression patterns in minutes, with far-reaching consequences for development, cell growth and homeostasis. The signal transducer and activator of transcription (STAT) proteins are among the most well studied of the latent cytoplasmic signal-dependent transcription-factor pathways. In addition to several roles in normal cell decisions, dysregulation of STAT function contributes to human disease, making the study of these proteins an important topic of current research.
nature.com