5-hydroxytryptamine type 3 receptor modulates opioid-induced hyperalgesia and tolerance in mice
DY Liang, XQ Li, JD Clark - The Journal of the American Society of …, 2011 - pubs.asahq.org
Background Opioid-induced hyperalgesia (OIH) and tolerance are challenging
maladaptations associated with opioids in managing pain. Recent genetic studies and the
existing literature suggest the 5-hydroxytryptamine type 3 (5-HT3) receptor participates in
these phenomena. The location of the relevant receptor populations and the interactions
between the 5-HT3 system and other systems controlling OIH and tolerance have not been
explored, however. We hypothesized that 5-HT3 receptors modulate OIH and tolerance, and …
maladaptations associated with opioids in managing pain. Recent genetic studies and the
existing literature suggest the 5-hydroxytryptamine type 3 (5-HT3) receptor participates in
these phenomena. The location of the relevant receptor populations and the interactions
between the 5-HT3 system and other systems controlling OIH and tolerance have not been
explored, however. We hypothesized that 5-HT3 receptors modulate OIH and tolerance, and …