Sulpiride, a D2/D3 blocker, reduces cataplexy but not REM sleep in canine narcolepsy
M Okura, J Riehl, E Mignot, S Nishino - Neuropsychopharmacology, 2000 - Elsevier
Cataplexy, an abnormal manifestation of REM sleep atonia, is currently treated with
antidepressants. These medications also reduce physiological REM sleep and induce
nocturnal sleep disturbances. Because a recent work on canine narcolepsy suggests that
the mechanisms for triggering cataplexy are different from those for REM sleep, we
hypothesized that compounds which act specifically on cataplexy, but not on REM sleep,
could be developed. Canine studies also suggest that the dopamine D2/D3 receptor …
antidepressants. These medications also reduce physiological REM sleep and induce
nocturnal sleep disturbances. Because a recent work on canine narcolepsy suggests that
the mechanisms for triggering cataplexy are different from those for REM sleep, we
hypothesized that compounds which act specifically on cataplexy, but not on REM sleep,
could be developed. Canine studies also suggest that the dopamine D2/D3 receptor …