[HTML][HTML] Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation
A Nikiforov, C Dölle, M Niere, M Ziegler - Journal of Biological Chemistry, 2011 - ASBMB
NAD is a vital redox carrier, and its degradation is a key element of important regulatory
pathways. NAD-mediated functions are compartmentalized and have to be fueled by specific
biosynthetic routes. However, little is known about the different pathways, their subcellular
distribution, and regulation in human cells. In particular, the route (s) to generate
mitochondrial NAD, the largest subcellular pool, is still unknown. To visualize organellar
NAD changes in cells, we targeted poly (ADP-ribose) polymerase activity into the …
pathways. NAD-mediated functions are compartmentalized and have to be fueled by specific
biosynthetic routes. However, little is known about the different pathways, their subcellular
distribution, and regulation in human cells. In particular, the route (s) to generate
mitochondrial NAD, the largest subcellular pool, is still unknown. To visualize organellar
NAD changes in cells, we targeted poly (ADP-ribose) polymerase activity into the …