Role of CXCR3 and CCR5 in allograft rejection

GT Schnickel, GR Hsieh, C Garcia, A Shefizadeh… - Transplantation …, 2006 - Elsevier
Chemokines are known to participate in allograft rejection by mediating leukocyte trafficking.
Despite redundancy in chemokine family, several chemokine-chemokine receptor
interactions have proven critical in alloimmune responses. We sought to determine the effect
of combined blockade of CXCR3 and CCR5, two critical chemokine receptors, in acute
rejection. METHODS: Heterotopic heart transplantation was performed using BALB/c to
B6/129 mice deficient in CCR5. Following transplantation these mice were treated with goat …