[HTML][HTML] Targeting amyloid-β peptide (Aβ) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Aβ …
EB Lee, LZ Leng, B Zhang, L Kwong… - Journal of Biological …, 2006 - ASBMB
Passive immunization of murine models of Alzheimer disease amyloidosis reduces amyloid-
β peptide (Aβ) levels and improves cognitive function. To specifically address the role of Aβ
oligomers in learning and memory, we generated a novel monoclonal antibody, NAB61, that
preferentially recognizes a conformational epitope present in dimeric, small oligomeric, and
higher order Aβ structures but not full-length amyloid-β precursor protein or C-terminal
amyloid-β precursor protein fragments. NAB61 also recognized a subset of brain Aβ …
β peptide (Aβ) levels and improves cognitive function. To specifically address the role of Aβ
oligomers in learning and memory, we generated a novel monoclonal antibody, NAB61, that
preferentially recognizes a conformational epitope present in dimeric, small oligomeric, and
higher order Aβ structures but not full-length amyloid-β precursor protein or C-terminal
amyloid-β precursor protein fragments. NAB61 also recognized a subset of brain Aβ …