Simultaneous PKC and cAMP activation induces differentiation of human dental pulp stem cells into functionally active neurons
M Kiraly, B Porcsalmy, A Pataki, K Kadar… - Neurochemistry …, 2009 - Elsevier
The plasticity of dental pulp stem cells (DPSCs) has been demonstrated by several studies
showing that they appear to self-maintain through several passages, giving rise to a variety
of cells. The aim of the present study was to differentiate DPSCs to mature neuronal cells
showing functional evidence of voltage gated ion channel activities in vitro. First, DPSC
cultures were seeded on poly-l-lysine coated surfaces and pretreated for 48h with a medium
containing basic fibroblast growth factor and the demethylating agent 5-azacytidine. Then …
showing that they appear to self-maintain through several passages, giving rise to a variety
of cells. The aim of the present study was to differentiate DPSCs to mature neuronal cells
showing functional evidence of voltage gated ion channel activities in vitro. First, DPSC
cultures were seeded on poly-l-lysine coated surfaces and pretreated for 48h with a medium
containing basic fibroblast growth factor and the demethylating agent 5-azacytidine. Then …