A biphasic response of hepatobiliary cholesterol metabolism to dietary fat at the onset of obesity in the mouse
S Roy, H Hyogo, SK Yadav, MK Wu, LA Jelicks… - Hepatology, 2005 - journals.lww.com
Human obesity is associated with abnormal hepatic cholesterol homeostasis and resistance
to leptin action. Because leptin administration to rodents promotes the biliary elimination of
plasma cholesterol, this study was designed to elucidate a pathophysiological role for leptin
during the development of obesity. We fed mice diets containing high or low saturated fat
contents. Before and after the onset of obesity, we measured downstream targets of leptin
action and evaluated plasma, hepatic, and biliary cholesterol metabolism. Although not …
to leptin action. Because leptin administration to rodents promotes the biliary elimination of
plasma cholesterol, this study was designed to elucidate a pathophysiological role for leptin
during the development of obesity. We fed mice diets containing high or low saturated fat
contents. Before and after the onset of obesity, we measured downstream targets of leptin
action and evaluated plasma, hepatic, and biliary cholesterol metabolism. Although not …