Anti-phospholipase A2 receptor antibodies correlate with clinical status in idiopathic membranous nephropathy
JM Hofstra, LH Beck Jr, DM Beck… - Clinical journal of the …, 2011 - journals.lww.com
Results 77.8% of iMN patients in our cohort had antibodies reactive with human PLA 2 R.
The antibody levels in these patients correlated strongly with both clinical status and
proteinuria (r= 0.73, P< 0.01). Conclusions The role of PLA 2 R as a major antigen in iMN
was confirmed in an independent, European patient cohort, and levels of circulating anti-
PLA 2 R revealed a strong correlation with clinical disease activity. We propose that
detection and measurement of these autoantibodies may provide a tool for monitoring of …
The antibody levels in these patients correlated strongly with both clinical status and
proteinuria (r= 0.73, P< 0.01). Conclusions The role of PLA 2 R as a major antigen in iMN
was confirmed in an independent, European patient cohort, and levels of circulating anti-
PLA 2 R revealed a strong correlation with clinical disease activity. We propose that
detection and measurement of these autoantibodies may provide a tool for monitoring of …
