A Case of Phospholipase A2 Receptor–Positive Membranous Nephropathy Preceding Sarcoid-Associated Granulomatous Tubulointerstitial Nephritis

M Knehtl, H Debiec, P Kamgang, P Callard… - American journal of …, 2011 - Elsevier
M Knehtl, H Debiec, P Kamgang, P Callard, J Cadranel, P Ronco, JJ Boffa
American journal of kidney diseases, 2011Elsevier
We report the case of a 29-year-old man with membranous nephropathy that was associated
with a sarcoidosic granulomatous tubulointerstitial nephritis, but was without an apparent
calcium metabolism disorder. Corticosteroid treatment was associated with remission of
nephrotic syndrome. We discuss the relationship between membranous nephropathy and
sarcoidosis based on the close appearance of the 2 diseases and the detection of
phospholipase A2 receptor in glomerular immune deposits.
We report the case of a 29-year-old man with membranous nephropathy that was associated with a sarcoidosic granulomatous tubulointerstitial nephritis, but was without an apparent calcium metabolism disorder. Corticosteroid treatment was associated with remission of nephrotic syndrome. We discuss the relationship between membranous nephropathy and sarcoidosis based on the close appearance of the 2 diseases and the detection of phospholipase A2 receptor in glomerular immune deposits.
Elsevier