Phospholipase A2 receptor (PLA2R1) sequence variants in idiopathic membranous nephropathy
MJH Coenen, JM Hofstra, H Debiec… - Journal of the …, 2013 - journals.lww.com
The M-type receptor for phospholipase A2 (PLA2R1) is the major target antigen in idiopathic
membranous nephropathy (iMN). Our recent genome-wide association study showed that
genetic variants in an HLA-DQA1 and phospholipase A2 receptor (PLA2R1) allele associate
most significantly with biopsy-proven iMN, suggesting that rare genetic variants within the
coding region of the PLA2R1 gene may contribute to antibody formation. Here, we
sequenced PLA2R1 in a cohort of 95 white patients with biopsy-proven iMN and assessed …
membranous nephropathy (iMN). Our recent genome-wide association study showed that
genetic variants in an HLA-DQA1 and phospholipase A2 receptor (PLA2R1) allele associate
most significantly with biopsy-proven iMN, suggesting that rare genetic variants within the
coding region of the PLA2R1 gene may contribute to antibody formation. Here, we
sequenced PLA2R1 in a cohort of 95 white patients with biopsy-proven iMN and assessed …
