The complement system is involved in defense against microorganisms, the processing of
immune complexes and apoptotic debris, and the development of an appropriate immune
response. Along with these physiologic effects, complement activation has the potential to
result in tissue pathology. To limit this, various complement regulatory proteins (CRP) are
present on host cells, including the glomerular podocyte. Experimental data from the
Heymann nephritis (HN) rat model of human membranous nephropathy (MN) have shown …