Umbilical cord blood transplantation: pros, cons and beyond
A Stanevsky, G Goldstein, A Nagler - Blood reviews, 2009 - Elsevier
Large body of clinical and scientific data has been generated since the first cord blood
transplantation (CBT) was performed in 1989. Superior immune plasticity of CB grafts, that
allows for less stringent HLA matching, is especially valuable in the face of a persistently
growing need for unrelated donor (UD) transplants. Limited cell dose remains the main
setback of CBT, particularly in adult population. New strategies, such as transplantation with
two cord blood units or using non-myeloablative conditioning, have remarkably expanded …
transplantation (CBT) was performed in 1989. Superior immune plasticity of CB grafts, that
allows for less stringent HLA matching, is especially valuable in the face of a persistently
growing need for unrelated donor (UD) transplants. Limited cell dose remains the main
setback of CBT, particularly in adult population. New strategies, such as transplantation with
two cord blood units or using non-myeloablative conditioning, have remarkably expanded …